PPI Lawsuit Medical Record Review Among the most popular therapies for acid reflux, gastroesophageal reflux disease (GERD), and other acid-related conditions are proton pump inhibitors (PPIs), which include routinely prescribed drugs like Nexium, Prilosec, Prevacid, and Protonix.  Long-term or high-dose PPI use has been connected to major health issues, such as renal disease, bone fractures, low magnesium levels, and other negative effects, even though PPIs are useful in lowe